Author

Salih Topal

Foghorn Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

David L. Lahr· 2 shared Gabriel J. Sandoval· 2 shared Jeremy W. SetseriD· 2 shared Kevin J. Wilson· 2 shared Steven F. Bellon· 2 shared Alexis Khalil· 1 shared Ammar Adam· 1 shared Asad M. TaherbhoyiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

David L. Lahr

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 1, 2025

Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription

Dipti Sadalge, Jozlyn R. Clasman, Salih Topal…·Asad M. Taherbhoy

This paper identifies the structural basis of PU.1-BAF interaction and shows small molecules can disrupt it, offering a new therapeutic strategy for cancer.

2 citations

humanprotein structure

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 11, 2023

Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

Richard C. Centore, Luis M. M. Soares, Salih Topal…·Steven F. Bellon

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

DOI 10.1101/2023.09.11.557162

mouseChIP-seq

𝕏 PostBluesky