Author

Sally A. Penfold

Baker Heart and Diabetes Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Josephine Maree ForbesiD· 3 shared Melinda T. CoughlaniD· 3 shared Aowen ZhuangiD· 2 shared Benjamin Luke SchulziD· 2 shared Brooke E. HarcourtiD· 2 shared Domenica A. McCarthy· 2 shared Felicia Y. T. Yap· 2 shared Karly C. Sourris· 2 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Josephine Maree ForbesORCID

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3 papers

Recent·Most cited

Molecular BiologyScientific ReportsPeer-reviewedSep 20, 2019

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy…·Josephine Maree Forbes

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

6 citations

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJul 22, 2019

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy…·Josephine Maree Forbes

This study shows that increased podocyte expression of oligosaccharyltransferase-48kDa subunit worsens diabetic kidney disease by causing endoplasmic reticulum stress and kidney dysfunction.

DOI 10.1101/710186

mouseproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMay 9, 2019

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

Brooke E. Harcourt, Aaron McClelland, Hiroshi Yamamoto…·Josephine Maree Forbes

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.

DOI 10.1101/632596

mousehuman

𝕏 PostBluesky