Author

Samantha M. Scott

Scripps Research Institute

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Genomics· 1

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Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Chao WangiD· 1 shared Darren M. Hutt· 1 shared Hao ShaoiD· 1 shared Jason E. GestwickiiD· 1 shared Pei ZhaoiD· 1 shared Shuhong Sun· 1 shared William E. BalchiD· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperGenomics

Chao WangORCID

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1 paper

Recent·Most cited

GenomicsHuman Molecular GeneticsPeer-reviewedSep 4, 2019

Managing the Spatial Covariance of Genetic Diversity in Niemann-Pick C1 Through Modulation of the Hsp70 Chaperone System

Chao Wang, Samantha M. Scott, Shuhong Sun…·William E. Balch

The paper shows that modulating the Hsp70 chaperone system improves NPC1 protein trafficking and stability across diverse genotypes by altering spatial covariance tolerance.

27 citations

humanprotein structure

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