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Samrat S. Mondal

University of California San Diego

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Approach:statistical model· 1

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Dominik WodarziD· 1 shared Natalia L. KomarovaiD· 1 shared

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Evolutionary BiologybioRxivPreprintNov 17, 2025

Spatial population structure can reverse the dependence of mutant burden on the death-to-birth ratio of cells

Samrat S. Mondal, Natalia L. Komarova, Dominik Wodarz

This paper shows spatial structure in cell populations can change how mutant burden depends on the death-to-birth ratio, explaining conflicting clinical observations about tumor turnover and patient outcomes.

DOI 10.1101/2025.11.17.688895

statistical model

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