Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1
Briana H. Greer, Javier Mendia-García, E.A. Mullins, Emma M. Peacock, Sander Haigh, Carl J. Schiltz, Clara Aicart-Ramos, Miaw-Sheue Tsai, David Cortez, Fernando Moreno‐Herrero, Brandt F. Eichman
This study reveals how SCFFBH1 promotes fork reversal and regulates RAD51 through DNA binding and ubiquitination, using cryo-EM structures and in vitro experiments.
Nature Communications · Jan 26, 2026Peer-reviewedBiochemistry