David Cortez

This study investigates how FET proteins and PARylation affect replication fork dynamics and genome stability upon PARG inhibition.

This study reveals how SCFFBH1 promotes fork reversal and regulates RAD51 through DNA binding and ubiquitination, using cryo-EM structures and in vitro experiments.

The paper investigates how abasic sites on leading and lagging strands affect replisome progression and bypass mechanisms in Xenopus egg extracts, showing distinct stalling effects but similar reliance on translesion synthesis.

The paper shows that replication fork collapse at SSBs leads to seDSBs resolved by homologous recombination, but DNA synthesis downstream is inefficient, while deDSBs allow efficient synthesis without recombination.

This study identifies factors influencing 8-oxoG-induced mutagenesis in human cells, revealing a hierarchical DNA repair network and chromatin structure effects on mutation patterns.

This paper shows that HLTF has two roles in managing G4s: preventing their accumulation and slowing replication forks to maintain genome stability.

This paper investigates the structure and mechanism of RADX, a negative regulator of RAD51 nucleofilaments, showing it caps and restricts RAD51 filament growth to regulate replication fork reversal.

The paper shows that HMCES-DNA protein crosslinks are resolved through self-reversal, which is crucial for managing ssDNA abasic sites and maintaining genome stability.

The paper identifies RADX separation of function mutants using CRISPR base editing screens, showing reduced RAD51 ATP hydrolysis activity and replication defects.