Miaw-Sheue Tsai

This study reveals how SCFFBH1 promotes fork reversal and regulates RAD51 through DNA binding and ubiquitination, using cryo-EM structures and in vitro experiments.

This study investigates the role of XPG interactions with TFIIH subunits p62 and XPD in nucleotide excision repair, showing their importance for catalytic activity and incision initiation.

The paper shows that MutL activates MPG to generate alkylation damage, contributing to cytotoxicity in MMS treatment.

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

This study shows that RNA damage can cause DNA breaks through R-loop formation, and YTHDC1-THOC prevents this by binding to m1A-modified RNAs.

This paper investigates the structure and mechanism of RADX, a negative regulator of RAD51 nucleofilaments, showing it caps and restricts RAD51 filament growth to regulate replication fork reversal.