LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia
Chi Gidley Weindel, Aja K. Coleman, Lily M Ellzey, Sandeep Kumar, Sara L Chaisson, Jacob R Davis, Kristin L. Patrick, Robert O. Watson
This study shows that LRRK2 kinase activity in microglia restricts NRF2-dependent mitochondrial protection, contrasting with its role in peripheral macrophages.
The Journal of Immunology · Sep 4, 2025Peer-reviewedImmunology