K. L. Patrick

The paper shows that reduced mitochondrial respiratory capacity in myeloid cells during Mtb infection impairs immune function and Mtb control, with similar findings in human data.

This study identifies Rv1075c as a Mycobacterium tuberculosis nucleomodulin that interacts with the SET1 histone methyltransferase complex, modulating host inflammation and lipid metabolism to promote bacterial persistence.

This study identifies Trim14's role in suppressing apoptosis via mitochondrial Stat3 during Mtb infection, enhancing antimycobacterial immunity.

This study identifies hnRNPA2B1 as a splicing regulator that modulates anti-mycobacterial immune responses in macrophages by controlling alternative splicing of Irgm1.

This study shows that LRRK2 kinase activity in microglia restricts NRF2-dependent mitochondrial protection, contrasting with its role in peripheral macrophages.

This study shows that mtDNA mutations in PolgD257A mice increase susceptibility to Mtb by impairing innate immunity and promoting necrosis.

This paper shows that the nuclear paraspeckle dynamically regulates inflammatory gene expression in macrophages, essential for controlling pathogen replication.

This study shows HNRNPA2B1 regulates IFNG signaling in macrophages by controlling IFNG receptor splicing and bacterial restriction.

This study identifies SRSF7's role in promoting the type I interferon response by transcriptionally activating IRF7 through cooperation with KMT5a.

This study identifies SRSF6 as a regulator of mitochondrial homeostasis in macrophages through alternative splicing of BAX, influencing immune responses and inflammation.

This study shows that pathogens like Brucella and coronavirus MHV exploit the RIDD pathway to degrade BLOS1, impairing lysosomal trafficking and enhancing their intracellular survival.

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

This study identifies PRMT5's role in modulating alternative splicing and Ca2+/NFAT signaling in activated T cells through symmetric dimethylation of RNA processing proteins.

This paper shows that Rhodococcus equi triggers type I interferons in macrophages via cytosolic DNA sensing, independent of its virulence plasmid.

This study identifies galectin-8 as a sensor for damaged Mtb-containing phagosomes that recruits TAX1BP1 to promote selective autophagy and control Mtb replication in macrophages.

This paper shows fungal hyaluronic acid interacts with host CD44 to recruit autophagy proteins to phagosomes, promoting fungal internalization via a Ca2+ -CaMKKβ-AMPK-ULK1 signaling pathway.

This study identifies splicing regulatory proteins' roles in modulating macrophage gene expression during infection, showing their impact on immune gene induction and viral restriction.

This study identifies TRIM14 as a negative regulator of the type I interferon response in macrophages during Mycobacterium tuberculosis infection, showing it enhances resolution of the response and limits bacterial replication.

This study shows LRRK2 regulates immune responses and neuroinflammation during Mycobacterium tuberculosis infection, linking it to neurodegenerative disease mechanisms.