Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors
Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott…·Caroline Jane Barelle
This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.