Hideki Aihara

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

This study engineers HUH-tags to form sequence-directed covalent bonds with RNA, enhancing their reactivity through directed evolution.

This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.

This study reports the crystal structure of SsdA, a bacterial ssDNA deaminase, revealing its unique substrate binding mechanism and sequence-independent activity.

This study enhances the oxygen affinity of the DosS protein by modifying its heme coordination sphere, achieving a 150-fold increase in O2 binding affinity.

The paper describes the creation and structural analysis of HbHNL variants with 40 and 71 mutations to resemble SABP2, showing increased structural similarity to SABP2 with more mutations.

This study models the full-length APOBEC3B structure and finds that NTD-CTD interactions increase active site opening frequency.

The paper develops a real-time biochemical assay to quantify APOBEC3-catalyzed DNA deamination and identify inhibitors.

The paper investigates the functional relationships among DUX family members, showing that DUXA acts as a competitive inhibitor of DUX4 and shares target gene overlap with it.

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.