Cell BiologybioRxivPreprint
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD
Sayan Ghosh, Ruchi Sharma, Sridhar Bammidi…·Debasish Sinha
This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.
DOI 10.1101/2023.08.08.552343