Author

Sean A. Higgins

Innovative Genomics Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein sequence· 1

Frequent Co-Authors

David F. SavageiD· 2 shared Arik ShamsiD· 1 shared Benjamin L. Oakes· 1 shared Brett T. Staahl· 1 shared Christof FellmanniD· 1 shared Jennifer A. DoudnaiD· 1 shared Madeline L. ArnoldiD· 1 shared Maria LukarskaiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

David F. SavageORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedSep 27, 2021

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Arik Shams, Sean A. Higgins, Christof Fellmann…·David F. Savage

The paper uses a genetic minimization technique to identify minimal DNA-binding modules in Cas9, showing that large domain deletions can retain function.

50 citations

experimental assayprotein design

𝕏 PostBluesky

Synthetic BiologyACS Synthetic BiologyPeer-reviewedJul 14, 2017

Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering

Sean A. Higgins, Sorel V. Yigma Ouonkap, David F. Savage

This paper demonstrates plasmid recombineering as a method for rapid and programmable protein mutagenesis, showing it can generate comprehensive libraries and identify improved variants.

25 citations

protein sequenceexperimental assay

𝕏 PostBluesky