Author

Sean Ruddy

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Bioinformatics· 1

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Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

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Elizabeth Purdom· 1 shared Marla Johnson· 1 shared

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2015-2015 · peak 1/yr

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Elizabeth Purdom

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1 paper

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BioinformaticsbioRxivJun 22, 2015

Shrinkage of dispersion parameters in the binomial family, with application to differential exon skipping

Sean Ruddy, Marla Johnson, Elizabeth Purdom

The paper introduces a shrinkage method for dispersion parameters in a binomial model to detect differential exon skipping in mRNA-Seq data, showing it is fast, powerful, and controls FDR well.

DOI 10.1214/15-aoas871

bulk RNA-seqstatistical model

𝕏 PostBluesky