GenomicsNucleic Acids ResearchPeer-reviewed
HOT or not: Examining the basis of high-occupancy target regions
Katarzyna Wreczycka, Vedran Franke, Bora Uyar…·Altuna Akalin
The paper investigates whether HOT regions are genuine transcription factor binding sites or ChIP-seq artifacts, finding they likely result from technical biases and specific sequence features.
66 citations