Author

Shaelyn R Marx

Johns Hopkins University

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Anna Lourdes CruziD· 1 shared Aswathy Peethambaran MallikaiD· 1 shared Grace D. BurnsiD· 1 shared Isabel De La Rosa· 1 shared Margarita Tsapatsis· 1 shared Meghraj Singh BagheliD· 1 shared Philip C. WongiD· 1 shared Shuying SuniD· 1 shared

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1 shared paperNeuroscience

Anna Lourdes CruzORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintJun 26, 2024

Depletion of TDP-43 exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau in a mouse model of Multiple Etiology Dementia

Meghraj Singh Baghel, Grace D. Burns, Margarita Tsapatsis…·Philip C. Wong

This paper shows that TDP-43 loss-of-function worsens tauopathy in a mouse model by increasing caspase 3-mediated tau cleavage in vulnerable neurons, leading to greater brain atrophy.

6 citations

mouseexperimental assay

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