Orai1α and Orai1β more potently promote NFAT activation and transcription than Orai2 and Orai3
Ahmed Emam Abdelnaby, Yin‐Hu Wang, Cory J. Benson, Isani Paolo Perez, Shen Mark, Maxwell McDermott, Miki Jishage, Amal Taher Elhaw, Silvia Cruz‐Rangel, Raphael J Courjaret, Abdelaziz Belkadi, Fang Yu, Douglas S Prado, Shuai Yuan, Ping Xin, , Mohamed Trebak
The paper compares the ability of different Orai isoforms to promote NFAT activation and transcription, finding Orai1α and Orai1β are more potent than Orai2 and Orai3.
bioRxiv · Oct 23, 2026 · PreprintCell Biology