Ping Xin

The paper compares the ability of different Orai isoforms to promote NFAT activation and transcription, finding Orai1α and Orai1β are more potent than Orai2 and Orai3.

This study shows that loss of STIM2 in colorectal cancer promotes tumor growth and metastasis through metabolic reprogramming and activation of the PERK-ATF4 ER stress pathway.