Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks
Samantha B. Regan, Darpan Medhi, Yuanlin Xu…·Maria Jasin
This study investigates LOH caused by CRISPR-Cas9 DSBs, showing large-scale loss and mechanisms, and highlights risks when combined with end joining inhibition.