Developmental BiologyeLifePeer-reviewed
T cell self-reactivity during thymic development dictates the timing of positive selection
Lydia Kay Lutes, Zoë Steier, Laura Lynn McIntyre…·Ellen A. Robey
This study shows that low self-reactive thymocytes have shorter TCR signals, delayed positive selection, and retain preselection gene expression signatures, suggesting ion channels modulate TCR sensitivity during development.
26 citations