PTBP1 is upregulated by Zika virus infection via HIF-1alpha signal and hijacks NS1 protein to induce NS1 degradation to restrain viral replication
Menglan Rao, Yue Kong, Shuang Liu…·Zhen Luo
This study identifies that ZIKV upregulates PTBP1 via HIF-1alpha, which then binds NS1 to promote its degradation, thereby inhibiting viral replication.