Cell BiologyCell Death and DiseasePeer-reviewed
Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity
Jules A Granet, Rebecca Robertson, Alessio A Cusmano…·Natasha C. Chang
This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.