Genetic & Genomic MedicinemedRxivPreprint
Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse
Eunkuk Park, Seung-Hee Yun, Hyun‐Seok Jin…·Seon‐Yong Jeong
This study shows that loss of Cotl1 in mice reduces platelet-mediated osteoclastogenesis, leading to osteopetrosis, and identifies a genetic association between COTL1 variants and bone density in humans.
DOI 10.1101/2023.12.20.23300337