Junctional Nanodomains Organised by Extended Synaptotagmin-1 Underlie Inflammatory Signalling in Sensory Neurons
Char Palfrey, James Grayston, Xiaoding Zhang, Yiting Gao, Sofia Figoli, Lilly Dougherty, Zhezhuyun Chen, Vincenzo Prato, Frederick Jones, Stephen W. Milne, Haxia Gao, Mark S. Shapiro, Nikita L. Gamper, Shihab Shah
This study identifies Esyt1 as a scaffold organizing ER-PM nanodomains that regulate inflammatory pain signaling through Ca2+-dependent interactions.
bioRxiv · Oct 29, 2026 · PreprintNeuroscience