The extremely low mechanical force generated by nano-pulling induces global changes in the microtubule network, nuclear morphology, and chromatin transcription in neurons
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello…·Vittoria Raffa
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Italian Institute of TechnologyORCID 0000-0002-2385-8320Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello…·Vittoria Raffa
Matteo Baggiani, María Andrea Desbats, Valentina Naef…·Devid Damiani
This study shows HPDL is essential for cortical development by regulating mitochondrial function and neurogenesis, with implications for SPG83 pathology and potential antioxidant therapies.
Soultana Konstantinidou, Agnieszka Lindstaedt, Tiziana Julia Nadjeschda Schmidt…·Vittoria Raffa
This paper presents a transfection-free method for delivering Cas9:gRNA ribonucleoprotein using gold nanoparticles, achieving effective gene editing in human melanoma cells.
Sara De Vincentiis, Matteo Baggiani, Francesca Merighi…·Vittoria Raffa
The paper shows that mechanical stimulation via magnetic nano-pulling accelerates neural precursor maturation into neurons and alters neuronal network organization.
Alessandro Falconieri, Sara De Vincentiis, Valentina Cappello…·Vittoria Raffa
This study shows that magnetic nano-pulling induces axonal cytoskeleton remodeling, enhancing outgrowth and synapse maturation through microtubule density increase and local translation promotion.