Generation of antigen-specific paired chain antibody sequences using large language models
Perry T. Wasdin, Nicole V. Johnson, Alexis K. Janke, Sofia Held, Toma M. Marinov, Gwen Jordaan, Léna Vandenabeele, Fani Pantouli, Rebecca A. Gillespie, Matthew J. Vukovich, Clinton Holt, Jeongryeol Kim, Grant S. Hansman, Jennifer K. Logue, Helen Y. Chu, , Ivelin S. Georgiev
This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.
bioRxiv · Dec 20, 2024 · PreprintBioinformatics