Alexandra A. Abu-Shmais

The paper identifies prefusion-specific human antibodies against HSV-2 gB that neutralize both HSV-1 and HSV-2 and protect neonatal mice.

The paper identifies a human antibody that neutralizes RSV and hMPV by targeting a novel epitope spanning multiple antigenic sites, showing cross-protection in a mouse model.

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

The paper maps antibody sequences to antigen specificity across multiple viral antigens, identifying convergent sequence features in antiviral B cells.

This paper designs antigen-specific antibody CDRH3 sequences using AI and germline-based templates, validated against SARS-CoV-2.

This paper evaluates multivalent HIV-1 Env immunization strategies in guinea pigs and adapts LIBRA-seq for antibody discovery, finding optimal cocktail sizes and identifying public clonotypes.

The paper introduces a negative binomial mixture model to denoise LIBRA-seq data, improving antigen binding predictions across multiple donors.