Daniel J. Sheward

This study uses synthetic coevolution to explore mutational trajectories between neutralizing antibodies and SARS-CoV-2 variants, revealing antagonistic and compensatory mutations.

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

This study shows that a monovalent XBB.1.5-adapted BNT162b2 booster vaccine enhances binding and neutralizing antibodies against XBB.1.5 and BA.2.86 in elderly individuals with prior vaccinations.

This paper introduces a Bayesian method to estimate HIV infection timing from unmutated sequences, avoiding data curation and providing accurate results robust to complications like APOBEC hypermutation.

This paper identifies an alpaca nanobody that neutralizes SARS-CoV-2 by blocking the ACE2 receptor interaction.