Genetic & Genomic MedicinemedRxivPreprint
A Favorable Modifiable Risk Factor Profile Mitigates Polygenic Risk for Alzheimers Disease and Related Dementia
Clayton O. Mansel, Soniya Mishra, Andrew Craver…·Olivia J. Veatch
This study shows that a favorable lifestyle reduces ADRD risk even in individuals with high polygenic risk, but APOE ε4 genotype remains a strong risk factor.
DOI 10.64898/2026.06.01.26354634