Generation of cloned sheep lacking galactose-α1,3-galactose and Nglycolylneuraminic acid antigens
Sarah Jane Appleby, LM Fermin, Zachariah L. McLean, Stephanie Delaney, Stefan Wagner, Cecilia Di Genova, Jingwei Wei, Fanli Meng, David N Wells, Björn J. Oback
This paper generates cloned sheep lacking two xenoantigens, Gal and Neu5Gc, by knocking out their respective genes, creating a model that better mimics human immune status for preclinical testing.
Xenotransplantation · May 1, 2026Peer-reviewedCell Biology