Author

Swetha Mahesula

Children's Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Florian StengeliD· 2 shared Marcel Wendel· 2 shared Samara L. Reck‐PetersoniD· 2 shared Sebastian MatheaiD· 2 shared Deep ChatterjeeiD· 1 shared Edward Owusu KwartengiD· 1 shared Erzsebet Kokovay· 1 shared Jacob ZielkeiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Florian StengelORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ascorbate is a physiological tumor suppressor metabolite in leukemia

Tobias Wijshake, Joseph Rose, Ji Hyung Jun, Edward Owusu Kwarteng, Xiaotong Yang, Jacob Zielke, Swetha Mahesula, Li Li, Stephen S. Chung, Stefano Comazzetto, Sean J. Morrison, Weina Chen, Michalis Agathocleous

This study shows that ascorbate deficiency in hematopoietic cells promotes leukemogenesis and identifies ascorbate as a tumor suppressor metabolite in blood cancers.

bioRxiv · Oct 21, 2026 · PreprintCancer Biology

Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation

Jasmin Jansen, Marcel Wendel, Nicolai D. Raig, Tom Kraus, Katherine J. Surridge, Swetha Mahesula, Nicole Richter-Muller, Sebastian Mathea, Samara L. Reck‐Peterson, Stefan Knapp, Florian Stengel

This study uses proximity labeling and phosphoproteomics to analyze LRRK1 and LRRK2 interactomes and phosphorylation sites, identifying novel substrates and the impact of inhibitors.

bioRxiv · Sep 3, 2025 · PreprintMolecular Biology

Selectivity profiles and substrate recognition of Rab phosphorylating kinases

Deep Chatterjee, Verena Dederer, Landon Vu Nguyen, Marcel Wendel, Kamal Rayees Abdul Azeez, Swetha Mahesula, Florian Stengel, Samara L. Reck‐Peterson, Sebastian Mathea

The paper identifies novel kinase:Rab pairs and characterizes substrate recognition determinants for Rab phosphorylation by kinases like LRRK2.

Biochemical Journal · Sep 1, 2025Peer-reviewedBiochemistry

Loss of LRP1 in adult neural stem cells impairs migration to ischemic lesions

Kristi Dietert, Swetha Mahesula, Sheetal Hegde, John Verschelde, Pamela Reed, Shane M. Sprague, Erzsebet Kokovay, Naomi L. Sayre

This study shows that loss of LRP1 in adult neural stem cells impairs their migration to ischemic lesions both in vivo and in vitro.

Stem Cells · Apr 25, 2023Peer-reviewedNeuroscience