Author

Joseph Rose

Children's Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ji Hyung JuniD· 4 shared Li LiiD· 4 shared Michalis AgathocleousiD· 4 shared Edward Owusu KwartengiD· 3 shared Jacob ZielkeiD· 3 shared Tobias WijshakeiD· 3 shared Weina CheniD· 2 shared Xiaotong Yang· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBiochemistry

Ji Hyung JunORCID

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4 papers

Recent·Most cited

Ascorbate and TET2 couple balanced hematopoiesis to disease tolerance

Tobias Wijshake, Joseph Rose, Ji Hyung Jun, Jacob Zielke, Li Li, Joseph S. Takahashi, Filipa Rijo‐Ferreira, Michalis Agathocleous

This study shows that ascorbate and TET2 promote balanced hematopoiesis, which is essential for surviving malaria and reducing disease severity.

bioRxiv · Nov 1, 2026 · PreprintImmunology

Ascorbate is a physiological tumor suppressor metabolite in leukemia

Tobias Wijshake, Joseph Rose, Ji Hyung Jun, Edward Owusu Kwarteng, Xiaotong Yang, Jacob Zielke, Swetha Mahesula, Li Li, Stephen S. Chung, Stefano Comazzetto, Sean J. Morrison, Weina Chen, Michalis Agathocleous

This study shows that ascorbate deficiency in hematopoietic cells promotes leukemogenesis and identifies ascorbate as a tumor suppressor metabolite in blood cancers.

bioRxiv · Oct 21, 2026 · PreprintCancer Biology

Loss of TCA cycle turning promotes stem cell function

Yafeng Li, Joseph Rose, Edward Owusu Kwarteng, Xiaotong Yang, Jacob Zielke, Li Li, Zhiyu Zhao, Ji Hyung Jun, Michalis Agathocleous

This study shows that TCA cycle turning is not essential for stem and progenitor cell survival or proliferation and its loss enhances stem cell function in hematopoiesis.

bioRxiv · Sep 23, 2026 · PreprintBiochemistry

Loss of vitamin C biosynthesis protects from a parasitic infection

Gongwen Chen, Ji Hyung Jun, Tobias Wijshake, Edward Owusu Kwarteng, Yunyang Li, Minwei Yuan, Joseph Rose, Shan Li, Sarah A. Cobb, Willow Serpa, Brayden Folger, Yafeng Li, L. Li, Weina Chen, James J. Collins, , Michalis Agathocleous

This study shows that ascorbate deficiency protects mice from schistosomiasis by impairing schistosome egg production and reducing disease severity.

Proceedings of the National Academy of Sciences · Dec 23, 2025Peer-reviewedBiochemistry