Stephen S. Chung

The paper detects malignant hematopoietic stem cells (HSCs) in myelodysplastic neoplasms (MDS) using low-input sequencing and shows they predict relapse after transplantation.

This study shows that ascorbate deficiency in hematopoietic cells promotes leukemogenesis and identifies ascorbate as a tumor suppressor metabolite in blood cancers.

The paper reports cryo-EM structures of cardiac AL amyloid fibrils from IGLV6 light chains, revealing conserved structural motifs and sequence-dependent folding mechanisms.

This study identifies low-variant allele frequency IDH1/2 mutations in sporadic angiosarcoma and shows they drive tumorigenesis through non-cell-autonomous mechanisms, responding to ivosidenib treatment.

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

The paper identifies missense mutations that create nuclear export signals, leading to disease, and shows therapeutic strategies can restore function.

The paper identifies a stress-specific erythroid progenitor population that links regenerative erythropoiesis to pathogenic erythrocytosis through Epo-IGF1R crosstalk.