Accumulation of SA-βGal High Cells in Human Naive T Cell Compartments Reveals a Stress-Adapted, Senescent-Like State
Andreea Cristina Alexandru, Genesis Vega Hormazabal, Hiroyuki Matsui, Herbert G. Kasler, Sierra Lore, Carlos Galicia Aguirre, Andrea Roberts, Indra Heckenbach, Ritesh Tiwari, Ryan Kwok, Sydney Becker, Eric M. Verdin
The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.
bioRxiv · Jun 10, 2025 · PreprintImmunology