Carlos Galicia Aguirre

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

The paper identifies and characterizes SA-βGal-high naive T cells that exhibit senescent-like features but retain proliferative capacity and cytotoxic properties, linking lysosomal-autophagic dysfunction to immune aging and inflammaging.

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

The paper uses single-cell RNA sequencing to study Huntington's disease by analyzing medium spiny neuron development in HD iPSC models and identifies potential therapeutic molecules.

The paper performs proteomic analysis of Huntington's disease patient-derived medium spiny neurons, identifying altered lipid metabolism and lipid droplet accumulation as key findings.

The paper identifies Foxf2 and Olig2 as key transcription factors regulating striatal compartmentation and neuronal differentiation through RNA- and ATAC-seq analysis of murine striosomes and matrix.