Author

Sylvie Syan

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Chiara ZurzoloiD· 2 shared Francesca PaleseiD· 2 shared Andrea ArmirottiiD· 1 shared Antonella ConsiglioiD· 1 shared Carmela GiachinoiD· 1 shared Carolina FilipponiiD· 1 shared Giulia SciandroneiD· 1 shared Giuliana Ottonello· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Chiara ZurzoloORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 2, 2026

An N-acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson s disease

Francesca Palese, Carmela Giachino, Sylvie Syan…·Chiara Zurzolo

This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.

DOI 10.64898/2026.03.19.712902

humanproteomics

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Cell BiologyNature CommunicationsPeer-reviewedMar 12, 2026

Neuronal Autophagy Failure Drives α-Synuclein Transfer to Microglia to Outsource Aggregate Clearance

Ranabir Chakraborty, Francesca Palese, Philippa Samella…·Chiara Zurzolo

The paper shows that neuronal autophagy failure leads to α-synuclein aggregate transfer to microglia, which then degrade them more efficiently.

12 citationstop 1%

humanproteomics

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