Cancer BiologybioRxiv
Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma
T. A. Bloedjes, G. de Wilde, C. Maas…·J. E. Guikema
This study shows that AKT inhibition in multiple myeloma activates FOXO and GSK3, leading to MCL1 reduction and cell death, suggesting potential for combination therapies.
DOI 10.1182/bloodadvances.2019001393