Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
Lipophilic Nanocrystal Prodrug-Release Defines the Extended Pharmacokinetic Profiles of a Year-Long Cabotegravir
N. Gauram, J. M. McMillan, D. Kumar…·Y. Alnouti
This study demonstrates that a nanoformulated CAB prodrug (NM2CAB) maintains plasma levels above the inhibitory concentration for up to one year, with sustained drug retention in tissues and macrophages.
DOI 10.1038/s41467-021-23668-x