Author

T. Aktepe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. White· 2 shared S. Fritzlar· 2 shared C. Wilen· 1 shared J. Deerain· 1 shared J. L. Hyde· 1 shared J. M. Mackenzie· 1 shared J. Mackenzie· 1 shared J. Pearson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

P. White

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2 papers

Recent·Most cited

Norovirus NS3 protein induces apoptosis through translation repression and dysregulation of BCL-2 pro-survival proteins

T. Aktepe, J. Deerain, S. Fritzlar, J. L. Hyde, J. Pearson, P. White, J. M. Mackenzie

This study identifies Norovirus NS3 protein as inducing apoptosis by repressing translation and dysregulating BCL-2 proteins, suggesting it as a potential antiviral target.

bioRxiv · Apr 23, 2023 · PreprintMicrobiology

Mouse Norovirus infection arrests host cell translation uncoupled from the stress granule-PKR-eIF2α axis

S. Fritzlar, T. Aktepe, Y.-W. Chao, M. McAllaster, C. Wilen, P. White, J. Mackenzie

This study shows that mouse norovirus infection suppresses host translation and cytokine production while promoting viral replication by recruiting G3BP1 to block stress granule formation.

bioRxiv · Jan 31, 2019Microbiology