J. Pearson

Adherent reformed islets: a long-term primary cell-based platform for exploring mouse and human islet biology.

This study develops a long-term primary cell-based platform called reformed islets to study mouse and human islet biology, showing they retain key physiological and functional features of native islets.

Global Sensitivity Analysis of the Onset of Nasal Passage Infection by SARS-CoV-2 With Respect to Heterogeneity in Host Physiology and Host Cell-Virus Kinetic Interactions

This study uses global sensitivity analysis to identify key factors driving variability in SARS-CoV-2 nasal infection outcomes, focusing on host physiology and cell-virus kinetics.

Norovirus NS3 protein induces apoptosis through translation repression and dysregulation of BCL-2 pro-survival proteins

This study identifies Norovirus NS3 protein as inducing apoptosis by repressing translation and dysregulating BCL-2 proteins, suggesting it as a potential antiviral target.

Gene expression profiling reveals B cells are highly educated by the pancreatic environment during autoimmune diabetes

The paper identifies transcriptional profiles of B cell subsets in the pancreas and lymph nodes, revealing their adaptation to the diabetic environment and potential role in autoimmune diabetes.

Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment

This study identifies bacterial lipopolysaccharides (LPS) that modulate immune responses in colorectal cancer subtypes, showing differential effects on cytokine production and immunogenicity.

Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

The paper models how mutations in SARS-CoV-2 delta and omicron variants alter viral load and infection outcomes by simulating different mechanistic changes.

Impact of sulfamethoxazole on a riverine microbiome

This study investigates the impact of sub-lethal sulfamethoxazole concentrations on river bacterial microbiomes using a flume system and omics approaches, finding limited effects on the resistome and no changes in ARG expression.

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

Low-dimensional learned feature spaces quantify individual and group differences in vocal repertoires

The paper uses a variational autoencoder to analyze vocal behavior in mice and zebra finches, showing it outperforms handpicked features in capturing variability and relationships.

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunity

A CD25-dependent IL-2 mutein selectively expands regulatory T cells and provides potent and targeted control of autoimmunity.

Variable expression quantitative trait loci analysis of breast cancer risk variants

This study identifies variable expression quantitative trait loci (veQTL) associated with breast cancer risk variants using GTEx data, revealing genes involved in steroid hormone biosynthesis and linking them to FTO allele effects.

APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.

MinION Sequencing of colorectal cancer tumour microbiomes - a comparison with amplicon-based and RNA-Sequencing

This study compares MinION sequencing with RNA-Sequencing and 16S rRNA amplicon sequencing for microbiome analysis of colorectal cancer samples, finding MinION's long reads can compensate for low read counts and detect more taxa.

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

This study identifies that Salmonella effectors SseK1 and SseK3 glycosylate death domain proteins in TNF and TRAIL signaling pathways, modulating their function during infection.