Author

J. L. Hyde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

R. Savan· 3 shared I. Salukhe· 2 shared J. J. Woodward· 2 shared J. Schwerk· 2 shared N. S. Gokhale· 2 shared S. A. Zaver· 2 shared A. E. L. Stone· 1 shared A. Forero· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

R. Savan

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5 papers

Recent·Most cited

Regulation of coronavirus nsp15 cleavage specificity by RNA structure

I. Salukhe, R. Choi, W. V. Voorhis, L. Barrett, J. L. Hyde

This study investigates how RNA secondary structure influences SARS-CoV-2 nsp15 endonuclease cleavage specificity, showing that stable structures protect RNA from cleavage and that uridine positioning within a pentaloop affects cleavage efficiency.

bioRxiv · May 12, 2023Microbiology

Norovirus NS3 protein induces apoptosis through translation repression and dysregulation of BCL-2 pro-survival proteins

T. Aktepe, J. Deerain, S. Fritzlar, J. L. Hyde, J. Pearson, P. White, J. M. Mackenzie

This study identifies Norovirus NS3 protein as inducing apoptosis by repressing translation and dysregulating BCL-2 proteins, suggesting it as a potential antiviral target.

bioRxiv · Apr 23, 2023 · PreprintMicrobiology

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

B. V. Tsu, R. Agarwal, N. S. Gokhale, J. Kulsuptrakul, A. P. Ryan, L. K. Castro, C. M. Beierschmitt, E. A. Turcotte, E. J. Fay, R. E. Vance, J. L. Hyde, R. Savan, P. S. Mitchell, M. D. Daugherty

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

bioRxiv · Sep 21, 2022Immunology

Sequence diversity in the 3' untranslated region of alphavirus modulates IFIT2-dependent restriction in a cell type-dependent manner

S. E. Hickson, E. Brekke, J. Schwerk, I. Salukhe, S. A. Zaver, J. J. Woodward, R. Savan, J. L. Hyde

This study shows that variability in the 3UTR of VEEV modulates IFIT2-dependent restriction, with differential sensitivity observed in vitro.

bioRxiv · Dec 10, 2021Microbiology

Endomembrane targeting of human OAS1 p46 augments antiviral activity

F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

bioRxiv · Apr 21, 2021Immunology