Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
X. Feng, T. Andersson, J. Gschwend, P. Flüchter, I. Berest, J. L. Muff, D. Carchidi, A. Lechner, J. C. de Tenorio, N. Brander, U. Boehm, C. S. Klose, D. Artis, T. Leinders-Zufall, F. Zufall, C. Schneider
The paper shows tuft cell IL-17RB limits IL-25 bioavailability, preventing excessive ILC2 activation and causing hypoproliferation under certain conditions.
bioRxiv · Mar 4, 2024Immunology