S. Jacques

REDD1 Regulates MERCS, Protein Synthesis and NMJ Stability in Fast Myofibers During Dexamethasone-Induced Muscle Wasting

Structure-function analysis of a calcium-independent metacaspase reveals a novel proteolytic pathway for lateral root emergence

This study solves the structure of a calcium-independent metacaspase and identifies inhibitors that block lateral root emergence in Arabidopsis.

Proteomic analysis revealed that the oomyceticide phosphite exhibits multi-modal action in an oomycete pathosystem.

This study uses proteomics to show phosphite affects both the oomycete pathogen and its host through multiple mechanisms, including metabolic disruption and immune response changes.

Chromatin-immunoprecipitation reveals the PnPf2 transcriptional network controlling effector-mediated virulence in a fungal pathogen of wheat

This study identifies PnPf2 as a central transcriptional regulator of virulence in Parastagonospora nodorum by characterizing its genomic targets and associated transcription factors.

Comparative sub-cellular proteome analyses reveals metabolic differentiation and production of effector-like molecules in the dieback phytopathogen Phytophthora cinnamomi.

This study compares the sub-cellular proteomes of Phytophthora cinnamomi to identify metabolic differences and effector-like molecules involved in pathogenicity.

Variability in an effector gene promoter of a necrotrophic fungal pathogen dictates epistasis and effector-triggered susceptibility in wheat

This study identifies a promoter element in the Tox1 gene of Parastagonospora nodorum that regulates effector expression and susceptibility in wheat, revealing its role in pathogen virulence and host resistance.

Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes

This study identifies heterozygous RELA mutations in early-onset SLE patients, showing they drive type-I interferon gene expression through NF-κB pathway hijacking.

Optical properties of living corals determined with diffuse reflectance spectroscopy

This study measures the optical properties of coral tissue and skeleton using diffuse reflectance spectroscopy to better understand light exposure for symbiotic algae.