X. Feng

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

New isolates refine the ecophysiology of the Roseobacter CHAB-I-5 lineage

The paper isolates two new CHAB-I-5 strains, analyzes their genomes, and proposes a new genus and species, highlighting ecological and physiological differences.

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread

This study identifies GP38 as a viral toxin causing vascular leak and shows that specific GP38-targeting antibodies block this effect in vitro and in vivo.

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

Highly accurate metagenome-assembled genomes from human gut microbiota using long-read assembly, binning, and consolidation methods

This study improves metagenome-assembled genomes from human gut microbiota using long-read sequencing and novel assembly methods, yielding more high-quality MAGs and uncovering uncultured diversity.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation

The paper shows tuft cell IL-17RB limits IL-25 bioavailability, preventing excessive ILC2 activation and causing hypoproliferation under certain conditions.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Reversibly-bonded Microfluidic Devices for Stable Cell Culture and Rapid, Gentle Cell Extraction

This paper introduces a reversible PDMS-PS bonding technique for microfluidic devices, enabling stable cell culture and gentle live cell extraction for downstream applications.

Metabolic imprints in the hydrogen isotopes of Archaeoglobus fulgidus tetraether lipids

This study investigates how metabolism and growth conditions affect hydrogen isotope signatures in archaeal lipids, supporting their use as paleohydrological proxies.

Sex chromosome turnover in hybridizing stickleback lineages

The paper identifies an ongoing sex chromosome turnover in hybridizing stickleback lineages, where younger homomorphic sex chromosomes replace older heteromorphic ones in admixed populations.

The evolution of multiply substituted isotopologues of methane during microbial aerobic oxidation

This study quantifies how temperature and methane monooxygenase enzymes affect clumped isotope signatures in aerobic methane oxidation by Methylococcus capsulatus (Bath).

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

3D Printed Ti3C2Tx MXene/PCL Scaffolds for Guided Neuronal Growth and Photothermal Stimulation

This paper develops 3D printed scaffolds with MXene coatings to guide neuronal growth and enable photothermal stimulation for neural circuit engineering.

A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.

DePARylation is critical for S phase progression and cell survival

This study shows that dePARylation by PARG is essential for S phase progression and cell survival, with PARG inhibition causing cytotoxicity through pADPr accumulation.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

The canonical single-stranded DNA binding protein SSB is not an essential replication protein but an RNA chaperon in the hyperthermophilic archaeon Saccharolobus islandicus REY15A

This study shows that the canonical SSB in Saccharolobus islandicus REY15A is not essential for DNA replication but functions as an RNA chaperone, with conserved activities in related archaea.

Micro-circulating hyperdynamic blood flow as a key pathogenic factor in early sepsis

This study identifies micro-circulating hyperdynamic blood flow as a universal pathogenic mechanism in early sepsis, leading to oxygen exchange disorder and hypoxia through the Bernoulli effect.

Ferroptosis induced by phenolic compound-iron complex

This study shows phenolic compounds induce ferroptosis via iron complex formation, leading to cell death in bacteria and mammals, with potential therapeutic and biotechnological applications.

Remodeling the central metabolism of Escherichia coli enables a universal chassis

This paper describes the construction of an E. coli strain with suppressed overflow metabolism, leading to improved chemical and protein production.

Structural basis of the T4 bacteriophage primosome assembly and primer synthesis

This study reports cryo-EM structures of T4 bacteriophage primosome assembly intermediates, revealing how the helicase and primase interact and synthesize RNA primers.

Cbp1-Cren7 chromatinization of CRISPR arrays favours transcription from leader- over cryptic promoters

The paper shows that Cbp1-Cren7 chromatinization suppresses cryptic promoter activity and enhances transcription from leader promoters in CRISPR arrays.

Determinants of genetic diversity in sticklebacks

The paper assesses genetic diversity in stickleback populations and finds demographic factors, not life history traits, primarily determine genetic diversity levels.

Chromosome-level genomes of multicellular algal sisters to land plants illuminate signaling network evolution

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

Time resolution in cryo-EM using a novel PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling

This paper introduces a microfluidic chip for time-resolved cryo-EM to study HflX-mediated ribosome recycling, capturing reaction intermediates at high resolution.

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling

The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.