In Vitro Safety Signals for Potential Clinical Development of the Anti-Inflammatory Pregnane X Receptor Agonist FKK6
Z. Dvorak, B. Vyhlidalov, P. Pecinkov, H. Li, P. Anzenbacher, a. spicakova, e. anzenbacherova, V. Chow, J. LIU, H. Krause, D. J. Wilson, T. Beres, P. Tarkowski, D. Chen, S. Mani
This paper performs in vitro pharmacological profiling of FKK6, showing high PXR selectivity, intestinal permeability, and rapid metabolism, supporting its potential preclinical development.
bioRxiv · Oct 21, 2023Biochemistry