Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis
S. Roy, T. Berida, S. R. McKee, S. Chatterjee, W. Li, P. Pandey, S. K. Tripathi, R. J. Doerksen, M. Jackson, C. Ducho, C. L. Stallings
This paper discovers and optimizes a new series of 1,2,4-triazolyl pyridines that inhibit Mycobacterium tuberculosis growth with nanomolar activity and favorable pharmacokinetics.
bioRxiv · Nov 14, 2022 · PreprintMicrobiology