M. Jackson

Terrestrial 3D Laser Scanning for Ecosystem and Fire Effects Monitoring

This paper introduces terrestrial laser scanning as an efficient, affordable method for ecosystem monitoring, enhancing data quality and repeatability through standardized data collection and automated analysis.

Body size is a better predictor of intra- than interspecific variation of animal stoichiometry across realms

The paper analyzes animal stoichiometry across species and body sizes, finding body size better predicts intraspecific than interspecific variation in elemental content.

Early NOTCH1 mutation is positively selected but epistatically suppresses evolution of later esophageal squamous-cell carcinoma drivers

The paper shows early NOTCH1 mutations are selected in normal tissue but suppress later cancer driver mutations through epistasis, highlighting stage-specific mutation effects in esophageal cancer.

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

Non-invasive canine electroencephalography (EEG): a systematic review

This review summarizes 22 non-invasive canine EEG studies, analyzing their methods, frameworks, and findings to suggest future directions in canine cognitive neuroscience.

Trade-offs in a reef-building coral after six years of thermal acclimation

This study shows that reef-building corals acclimate to elevated temperatures by increasing energy storage but at the cost of reduced skeletal growth, with potential implications for reef development.

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

This paper discovers and optimizes a new series of 1,2,4-triazolyl pyridines that inhibit Mycobacterium tuberculosis growth with nanomolar activity and favorable pharmacokinetics.

A Multivalent Polyomavirus Vaccine Elicits Durable Neutralizing Antibody Responses in Macaques

This study shows a multivalent polyomavirus vaccine induces high, durable neutralizing antibodies in macaques without adverse effects.

Mechanical morphotype switching as an adaptive response in mycobacteria

The paper shows mycobacteria change their cell surface stiffness to survive macrophage stress, using mechanical morphotype switching as an adaptive strategy.

Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

Beyond coral-algal regimes: high taxonomic resolution surveys and trait-based analyses reveal multiple benthic regimes

The paper uses high taxonomic resolution and trait-based analyses to identify multiple benthic regimes on coral reefs, showing that major taxonomic categories fail to detect distinct regimes.

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

Pathway dynamics can delineate the sources of transcriptional noise in gene expression

This paper mathematically formalizes transcriptional noise decomposition and shows that pathway reporters can replace dual reporters for noise analysis in single-cell data.

ASO-based PKM Splice-switching Therapy Inhibits Hepatocellular Carcinoma Cell Growth

This paper demonstrates that ASO-based PKM splice-switching therapy inhibits HCC cell growth by converting PKM2 to PKM1, altering glucose metabolism and reducing tumorigenesis.

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

Cytokinin signaling in Mycobacterium tuberculosis

This study shows Mycobacterium tuberculosis uses cytokinins, previously known as plant hormones, to induce gene expression affecting its cell envelope.