Author

T. Bernauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. G. W. Gertzen· 2 shared D. Steinritz· 2 shared F. F. Paintner· 2 shared F. Worek· 2 shared H. Gohlke· 2 shared J. Kaiser· 2 shared K. T. Wanner· 2 shared K. V. Niessen· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. G. W. Gertzen

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2 papers

Recent·Most cited

Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents

T. Bernauer, V. Nitsche, J. Kaiser, C. G. W. Gertzen, G. Hoefner, K. V. Niessen, T. Seeger, D. Steinritz, F. Worek, H. Gohlke, K. T. Wanner, F. F. Paintner

This study synthesizes and evaluates new MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after nerve agent intoxication, identifying more potent compounds than MB327.

bioRxiv · Feb 9, 2024Pharmacology & Toxicology

Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs

J. Kaiser, C. G. W. Gertzen, T. Bernauer, V. Nitsche, G. Höfner, K. V. Niessen, T. Seeger, F. F. Paintner, K. T. Wanner, D. Steinritz, F. Worek, H. Gohlke

This paper identifies novel ligands binding to MB327-PAM-1, a binding site for resensitizing nAChRs, including cycloguanil, which shows higher affinity and functional efficacy.

bioRxiv · Dec 21, 2023Pharmacology & Toxicology