Pharmacology & ToxicologybioRxiv
Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
J. Kaiser, C. G. W. Gertzen, T. Bernauer…·H. Gohlke
This paper identifies novel ligands binding to MB327-PAM-1, a binding site for resensitizing nAChRs, including cycloguanil, which shows higher affinity and functional efficacy.
DOI 10.1016/j.toxlet.2024.05.013