J. Kaiser

Local FK506 delivery induces osteogenesis in in vivo rat bone defect and rabbit spine fusion models

This study shows FK506 induces bone formation in human cells and two in vivo models, and can be used alone or with BMP-2 for spine disorders.

Decoding the Baltic Sea's Past and Present: A simple Molecular Index for Ecosystem Assessment

This paper develops a DNA-based index using ancient sediment DNA to assess past and present phytoplankton dominance in the Baltic Sea, revealing historical shifts in species composition.

Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents

This study synthesizes and evaluates new MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after nerve agent intoxication, identifying more potent compounds than MB327.

Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of SF3B1 mutations

This study uses long-read transcriptome sequencing to analyze SF3B1 mutations in CLL and MDS patients, revealing common splicing alterations and their impact on disease prognosis.

Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs

This paper identifies novel ligands binding to MB327-PAM-1, a binding site for resensitizing nAChRs, including cycloguanil, which shows higher affinity and functional efficacy.

MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor

The paper establishes MS Binding Assays using UNC0642 as a reporter ligand to study the MB327 binding site of the nicotinic acetylcholine receptor, showing its effectiveness in both in vitro and in silico studies.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

InCellCryst - A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins

InCellCryst produces homogeneous protein microcrystals within living insect cells, enabling X-ray diffraction data collection without protein purification.

Light-dependent Control of Bacterial Expression at the mRNA Level

This paper develops optogenetic systems using the PAL photoreceptor to control bacterial gene expression at the mRNA level through light-responsive RNA aptamers.

Financial incentives facilitate the neural computation of prosocial decisions stronger in low empathic individuals

This study shows financial incentives enhance prosocial motivation in low empathic individuals by increasing anterior insula activation, with less effect on high empathic individuals.

Multichromatic Near-Infrared Imaging to Assess Interstitial Lymphatic and Venous Uptake In Vivo

This study uses multichromatic near-infrared imaging with tracers to assess in vivo lymphatic and venous fluid clearance in different tissues and under exercise conditions.

Effects of osteogenic ambulatory mechanical stimulation on early stages of BMP-2mediated bone repair

This study investigates how mechanical loading affects early bone repair stages in a rat model, showing changes in cytokine expression, angiogenesis, and endochondral ossification.

DoUble resin Casting micro computed Tomography (DUCT) reveals biliary and vascular pathology in a mouse model of Alagille syndrome

The paper introduces DUCT, a method to image and quantify 3D biliary and vascular structures in mouse livers, revealing novel phenotypes in Alagille syndrome models and human patients.

Real-time monitoring of mechanical cues in the regenerative niche reveal dynamic strain magnitudes that enhance bone repair

This study uses an implantable strain sensor to monitor mechanical cues during bone repair in rats, showing that dynamic strain magnitudes correlate with healing status.